비알코올성 지방간 질환 환아에서의 체질량 분석의 유용성

비알코올성 지방간 질환 환아에서의 체질량 분석의 유용성

Body composition chart in boys with non-alcoholic fatty liver disease

(포스터):泥
Release Date : 2017. 10. 26(목)
choi minhye, lee seonhwa, bae sunhwan , Chung sochung
Konkuk University Hospital pediatrics 1
최민혜, 이선화, 배선환 , 정소정
건국대학교병원 소아청소년과 1

Abstract

Background> Non-alcoholic fatty liver disease (NAFLD) is considered to be the most common causes of chronic liver disease in children. It can be screened by risk factors, helping early detection of NAFLD. Checking body mass index (BMI) as a single parameter has limitation, as some sarcopenic obese person, who has normal range of BMI, cannot be aware of the disease. We suggest considering the overall body composition, and draw a body composition (BC) chart composed of BC indices, including BMI and PBF to visualize the risk of NAFLD in obese children. Material and Method> Thirty-eight boys, diagnosed as NAFLD by abdomen sonography, were selected retrospectively from whom visited Konkuk University Medical Center 2006 to 2015. They had gone through body composition analysis with bioelectrical impedance analysis (BIA) and blood biochemistry including liver function test (LFT) and lipid panel. Those who had other cause for abnormal LFT such as viral hepatitis was excluded. Fat free mass index (FFMI) and fat mass index (FMI) were calculated with FFM and FM from BC analysis and height. Plotted coordinates of FFMI and FMI, along with the reference lines of BMI and PBF, visualized the boy\'s character of body composition. We divide zones by certain value of BMI and PBF and sorted the zone A to D. The correlations between blood biochemistry; LFT, lipid panel, and the body composition indices were analyzed. Results> Thirty-four boys were over the BMI value 23, and thirty-seven boys showed PBF over 30. BMI of 23, and PBF of 30 approximately correspond to the 85th percentile of 13-year-old boy, the mean age of this study, and were chosen as a reference line. Thirty-three boys were located in zone C. Four boys were located in zone D, which indicates sarcopenic obesity. One boy who is located zone B indicates the masculine boy. In the correlation analysis, ALT level had positive correlation with BMI Z score (BMIZ), PBF and FMI. Conclusion> BC chart might be a useful screening tool in risk assessment in obesity related disease such as NALFD. Zones on BC chart could be practical, especially in sarcopenic obese population either in children or elderlies. Personalized values of BC chart components should be applied at the individual level in clinical practice.

Keywords: body composition, non-alcoholic fatty liver disease, childhood obesity